The song, featuring Justin Bieber, Quavo, Chance the Rapper & Lil Wayne, is Khaled's first Hot 100 leader.

DJ Khaled's "I'm the One," featuring Justin Bieber, Quavo, Chance the Rapper and Lil Wayne, launches at No. 1 on the Billboard Hot 100 chart (dated May 20). The high-profile collab, released on We the Best/Def Jam/Epic Records, is the first Hot 100 leader for Khaled (who co-produced and co-wrote it and adds vocals) and Chance the Rapper, as well as the first for Quavo, of rap act Migos, as a soloist. Bieber earns his fourth No. 1 and Lil Wayne scores his third.

The song dethrones Bruno Mars' "That's What I Like" after a week at No. 1 on the Hot 100, although it takes over atop the Radio Songs chart.

Bieber goes fourth: Notably, Bieber has now earned more top five Hot 100 hits after his 2015 album Purpose than he did from the set: following the LP's No. 1s "Mean," "Sorry" and "Love Yourself," he's added four top fives in featured roles, on Major Lazer's "Cold Water" (also featuring MO; No. 2); DJ Snake's "Let Me Love You" (No. 4); Luis Fonsi and Daddy Yankee's "Despacito" (up to No. 3 this week, see below); and now Khaled's No. 1 "One."

Rounding out the Hot 100's top five, Lamar's "Humble." falls 3-4 and Sheeran's former 12-week Hot 100 No. 1 "Shape" slides 2-5.

Capping the Hot 100's top 10, The Chainsmokers and Coldplay's No. 3-peaking "Something Just Like This" holds at No. 6 (as The Chainsmokers spend a 53rd consecutive week in the top 10). On Hot Dance/Electronic Songs, "Something" logs an eighth total week at No. 1. Future's "Mask Off" drops to No. 7 from its No. 5 Hot 100 peak, followed by three songs that each stay in place: Kyle's "iSpy," featuring Lil Yachty (No. 8, after hitting No. 4); Lil Uzi Vert's "XO TOUR Llif3" (No. 9, after reaching No. 8); and Kygo and Selena Gomez's "It Ain't Me," which keeps at its No. 10 high after entering the region a week ago.